Determinants of exercise capacity in hypertrophic cardiomyopathy
نویسندگان
چکیده
منابع مشابه
Prognostic Determinants in Hypertrophic Cardiomyopathy
Background. Patients with hypertrophic cardiomyopathy (HCM) frequently have arrhythmias and hemodynamic abnormalities and are prone to sudden death and syncope. An important need exists for improved risk stratification and definition of appropriate investigation and therapy. Methods and Results. The relation of31 clinical, Holter, cardiac catheterization, and electrophysiological (EP) variables...
متن کاملExercise Physiology Metabolic Modulator Perhexiline Corrects Energy Deficiency and Improves Exercise Capacity in Symptomatic Hypertrophic Cardiomyopathy
Background—Hypertrophic cardiomyopathy patients exhibit myocardial energetic impairment, but a causative role for this energy deficiency in the pathophysiology of hypertrophic cardiomyopathy remains unproven. We hypothesized that the metabolic modulator perhexiline would ameliorate myocardial energy deficiency and thereby improve diastolic function and exercise capacity. Methods and Results—For...
متن کاملHemodynamic determinants of exercise-induced abnormal blood pressure response in hypertrophic cardiomyopathy.
OBJECTIVES We sought to assess the hemodynamics of exercise in patients with hypertrophic cardiomyopathy (HCM), with and without an exercise-induced abnormal blood pressure (BP) response, by ambulatory radionuclide monitoring of left ventricular (LV) function with the VEST device (Capintec Inc., Ramsey, New Jersey). BACKGROUND Blood pressure fails to increase >20 mm Hg during exercise in abou...
متن کاملHypertrophic cardiomyopathy: exercise and eat right.
that arises from mutations in genes encoding the proteins of the sarcomere. Although 9 different sarcomere genes have been implicated, point mutations in the gene encoding the heavy chain of myosin (Myh7) or myosin binding protein C (MyBPC3) are responsible for more than half of genetically confirmed cases of HCM.2 Clinical management of HCM revolves around 2 significant issues: (1) reducing he...
متن کاملVagal determinants of exercise capacity
Indirect measures of cardiac vagal activity are strongly associated with exercise capacity, yet a causal relationship has not been established. Here we show that in rats, genetic silencing of the largest population of brainstem vagal preganglionic neurons residing in the brainstem's dorsal vagal motor nucleus dramatically impairs exercise capacity, while optogenetic recruitment of the same neur...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1989
ISSN: 0735-1097
DOI: 10.1016/0735-1097(89)90342-2